The effectiveness of RNA-based therapeutics depends heavily on their precise delivery to target tissues and cells, but the underlying biological mechanisms of RNA delivery and intracellular distribution remain poorly understood. Factors such as RNA size, chemistry, modifications, and structure play a crucial role in influencing tissue delivery and intracellular distribution by affecting interactions with proteins and other biological macromolecules. Additionally, cell-type specific differences in RNA-binding protein (RBP) expression contribute to the tissue-specificity of RNA uptake and distribution. Understanding and manipulating these mechanisms is essential for designing next-generation delivery platforms that enhance the efficacy and safety of RNA therapeutics. This research cluster aims to bridge this gap and facilitate future development of effective RNA therapeutics.
