Cluster 2

RNA Modifications and Host Immunity

RNA modifications are pivotal in modulating innate and adaptive immune responses, yet their role is not yet fully understood. Dysregulated immune control via RNA modifications is implicated in various human diseases. Conversely, RNA modifications can “cloak” therapeutic RNAs or vaccines, preventing their recognition or destruction by the host immune system, which is crucial for developing RNA therapeutics. This research cluster aims to elucidate the mechanisms and connections between RNA modifications and host immunity, addressing a major unresolved challenge with significant translational potential for improving RNA-based vaccines and therapeutics.

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Cluster Chairs

Polly Leilei CHEN
Associate Director & Principal Investigator
Cancer Science Institute of Singapore,
National University of Singapore (NUS)
Assistant Head & Associate Professor
Department of Anatomy, Yong Loo Lin School of Medicine,
National University of Singapore (NUS)
Wei WU
Principal Investigator
A*STAR Singapore Immunology Network (SIgN)
Associate Professor
Department of Pharmacy & Pharmaceutical Sciences,
National University of Singapore (NUS)

Cluster Members

Wei Leong CHEW
Senior Principal Scientist
A*STAR Genome Institute of Singapore (GIS)
Adjunct Assistant Professor
National University of Singapore (NUS)
Jonathan GÖKE
Assistant Director & Group Leader
A*STAR Genome Institute of Singapore (GIS)
Adjunct Associate Professor,
Department of Statistics and Data Science,
National University of Singapore (NUS)
Melissa NG
Group Leader
A*STAR Singapore Immunology Network (SIgN)
Liang Wei WANG
Group Leader
A*STAR Singapore Immunology Network (SIgN)
Jiangbo WEI
Principal Investigator
Cancer Science Institute of Singapore,
National University of Singapore (NUS)
Presidential Young Professor
Department of Chemistry, Department of Biological Sciences,
National University of Singapore (NUS)
Ruyi ZHU
Presidential Young Professor
Department of Chemistry,
National University of Singapore (NUS)