Impact of Asian Genetic Diversity on the RNA Biology of Disease
Genetic diversity within Asian populations is underrepresented in global RNA biology research, despite its significant impact on the understanding of disease mechanisms, progression, and therapy response. It addresses the challenge of identifying how unique genetic variants affect RNA biology and contribute to diseases like cancer and cardiometabolic syndromes. By leveraging Singapore’s unique genetic diversity and integrating the whole-genome sequence data and deep phenomic data generated by PRECISE in the SG100K cohort, as well as novel model systems. The research aims to create a rich catalogue of RNA variations and their functional effects in diseases relevant to Asian population and Singapore.
